Gene

Cytogenetic band locus

Known and putative functional genomics

DD3 or PCA3 Prostate cancer antigen 3

9q21.2

Non coding and highly over-expressed in Prostate Cancer specimens [45] [46] . No known relationship with SPTLC1 although in close genomic proximity.

BIP/GRP78 78 kDa glucose-regulated protein.

9q33.3

An ER lumen integrated stress response-related protein, implicated in the unfolded protein response and cancer progression pathways [66] . It binds SPTLC1 in Hek3 human kidney cancer cell line [3] .

ABL1 c-abl oncogene 1

9q34.1

A non-receptor tyrosine-protein kinase linked to key processes regulating cell differentiation, division, adhesion, motility, stress response and death. Reciprocal translocation of ABL1 oncogene to 22q11 creates the BCR/ABL1 fusion gene, a cytogenetic hallmark of chronic myeloid leukemia [48] [67] . ABL phosphorylates SPTLC1 at Tyr(164). Mutating Tyr(164) to Phe in SPTLC1, increasing SPT enzyme activity and apoptotic sensitization of cultured K562 cells [68] [69] .